Table 1.
Crude and adjusted rate ratios (RR) for occurence of AIDS disease or death from a Poisson regression model
| Rate ratio (95% Cl) P-value | ||||
|---|---|---|---|---|
| Univariable | Multivariable | |||
| Nucleoside pair | ||||
| AZT/3TC | 1.05 (0.84–1.34) | P = 0.66 | 1.21 (0.93–1.58) | P = 0.15 |
| d4T/ddl | 1.08 (0.86–1.36) | P = 0.49 | 1.26 (0.97–1.62) | P = 0.08 |
| d4T/3TC | 0.98 (0.72–1.32) | P = 0.87 | 1.15 (0.84–1.58) | P = 0.38 |
| other | 1.00 | 1.00 | ||
| Third drug | ||||
| indinavir | 1.00 | 1.00 | ||
| ritonavir | 1.14 (0.84–1.54) | P = 0.41 | 0.88 (0.66–1.17) | P = 0.39 |
| saquinavir | 1.80 (1.36–2.41) | P < 0.0001 | 1.04 (0.78–1.38) | P = 0.80 |
| nelfinavir | 0.78 (0.59–1.02) | P = 0.069 | 0.99 (0.76–1.28) | P = 0.92 |
| IDV/r of SQV/r | 0.56 (0.41–0.77) | P = 0.0004 | 0.79 (0.59–1.05) | P = 0.10 |
| Iopinavir/r | 1.04 (0.69–1.57) | P = 0.83 | 1.08 (0.65–1.82) | P = 0.76 |
| abacavir* | 0.72 (0.49–1.05) | P = 0.09 | 1.01 (0.64–1.60) | P = 0.97 |
| nevirapine | 0.57 (0.42–0.78) | P = 0.0004 | 0.91 (0.65–1.28) | P = 0.59 |
| efavirenz | 0.62 (0.46–0.84) | P = 0.002 | 0.83 (0.57–1.20) | P = 0.31 |
NB. RR = rate ratio per extra year; # counted only when 3rd drug; Indinavir = IDV; Ritonavir = r; Saquinavir = SQV; AZT = ZDV = zidovudine; 3TC = lamivudine; d4T = stavudine; ddl = didanosine.