Table 1.

The Effect of IL-29 in Human Cancers.

Cancer type	Effect	Cell lines	Mechanism	Reference
Multiple myeloma	Promotion	KAS-6/1 and KP-6 MM	↑Activation of STAT1 and STAT3	Novak et al. (2008)
Gastric	Inhibition	SGC-7901 and HGC-27	↓Bcl-2 and ↑caspase cascades	Gao et al. (2014)
Colorectal	Inhibition	C26	↑NK and NKT cell activity	Aulino et al. (2010)
Glioblastoma	Inhibition	LN319	Unknown	Meager et al. (2005)
Liver	Inhibition	BEL-7402	Unknown	Lu et al. (2015)
Lung	Inhibition	Sq-1, Sq-19, LK-1, LK-2, OBA-LK1, 11–18, LK-79, 86-2, Lu99, EBC-1 and A549	↑p21 by STAT pathway	Fujie et al. (2011),Barrera et al. (2015)
Esophagus	Inhibition	TE-1, TE-2, TE-10, TE-11, YES-2, YES-4, YES-5, YES-6 and T.Tn	↑MHC Class I, ↑p21, ↑Rb protein	Li et al. (2010)
Skin	Inhibition	A375, B16, Hs294T, and SK-MEL-5	↑MHC Class I, ↑p21, ↑Rb protein	Merritt et al. (2004), Romee et al. (2014), Sato et al. (2006), Yen and Varvayanis (1994)

↑: Upregulate/increase ↓: Downregulate/decrease.