Table 1.
ESI-Mass Spectrometric Characterization of Synthesized Linear Substrates
| Compound | Sequence | Species (m/z) | Observed Mass (Calculated Mass) |
|---|---|---|---|
| GS2 | d-Phe1- l-Leu2- SNAC | [M + H]+ | 380.2 (380.2) |
| GS3 | d-Phe1- l-Pro2- l-Leu3- SNAC | [M + H]+ | 477.2 (477.3) |
| GS4 | d-Phe1- l-Pro2- l-Orn3- l-Leu4- SNAC | [M + H]+ | 591.2 (591.3) |
| GS5SNAC | d-Phe1- l-Pro2- l-Val3- l-Orn4- l-Leu5- SNAC | [M + H]+ | 690.5 (690.4) |
| GS5SPh | d-Phe1- l-Pro2- l-Val3- l-Orn4- l-Leu5- SPh | [M + H]+ | 681.5 (681.4) |
| GS5Ala2 | d-Phe1- l-Ala2- l-Val3- l-Orn4- l-Leu5- SNAC | [M + H]+ | 664.5 (664.4) |
| GS5Ala3 | d-Phe1 -l-Pro2 -l-Ala3 -l-Orn4 -l-Leu5 -SNAC | [M + H]+ | 662.5 (662.4) |
| GS5Ala4 | d-Phe1- l-Pro2- l-Val3- l-Ala4- l-Leu5- SNAC | [M + H]+ | 647.4 (647.4) |
| GS5l-Phe1 | d-Phe1- l-Pro2- l-Val3- l-Orn4- l-Leu5- SNAC | [M + H]+ | 690.5 (690.4) |
| GS5d-Leu5 | d-Phe1- l-Pro2- l-Val3- l-Orn4- d-Leu5- SNAC | [M + H]+ | 690.5 (690.4) |
| GS5NAc | NAc-d-Phe1- l-Pro2- l-Val3- l-Orn4- l-Leu5- SNAC | [M + H]+ | 732.4 (732.4) |
| GS5OH | d-Phe1- l-Pro2- l-Val3- l-Orn4- l-Leu5 | [M + H]+ | 589.4 (589.4) |
| GS6 | d-Phe1- l-Pro2- l-Val3- l-Val4- l-Orn5- l-Leu6- SNAC | [M + H]+ | 789.5 (789.5) |
| GS7 | d-Phe1- l-Pro2- l-Val3- l-Pro4- l-Val5- l-Orn6- l-Leu7- SNAC | [M + H]+ | 886.5 (886.5) |
| GS8 | d-Phe1- l-Pro2- l-Val3- l-Orn4- l-Pro5- l-Val6- l-Orn7- l-Leu8- SNAC | [M + H]+ | 1000.6 (1000.6) |
| GS9 | d-Phe1- l-Pro2- l-Val3- l-Orn4- l-Leu5- l-Pro6- l-Val7- l-Orn8- l-Leu9- SNAC | [M + H]+ | 1113.8 (1113.7) |
| GS10 | d-Phe1- l-Pro2- l-Val3- l-Orn4- l-Leu5- d-Phe6- l-Pro7- l-Val8- l-Orn9- l-Leu10- SNAC | [M + H]+ | 1260.7 (1260.7) |
| GS10l-Phe1 | l-Phe1- l-Pro2- l-Val3- l-Orn4- l-Leu5- d-Phe6- l-Pro7- l-Val8- l-Orn9- l-Leu10- SNAC | [M + H]+ | 1260.7 (1260.7) |
| GS10d-Leu10 | d-Phe1- l-Pro2- l-Val3- l-Orn4- l-Leu5- d-Phe6- l-Pro7- l-Val8- l-Orn9- d-Leu10- SNAC | [M + H]+ | 1260.7 (1260.7) |
| GS10Ala2,7 | d-Phe1- l-Ala2- l-Val3- l-Orn4- l-Leu5- d-Phe6- l-Ala7- l-Val8- l-Orn9- l-Leu10- SNAC | [M + H]+ | 1208.7 (1208.7) |
| GS10Ala3,8 | d-Phe1- l-Pro2- l-Ala3- l-Orn4- l-Leu5- d-Phe6- l-Pro7- l-Ala8- l-Orn9- l-Leu10- SNAC | [M + H]+ | 1204.7 (1204.7) |
| GS10Ala4,9 | d-Phe1- l-Pro2- l-Val3- l-Ala4- l-Leu5- d-Phe6- l-Pro7- l-Val8- l-Ala9- l-Leu10- SNAC | [M + H]+ | 1174.7 (1174.7) |