| Biological Matrices | Plasma | Skin Blister Fluid |
|---|---|---|
| N | 8 | 8 |
| Cmax (μg/mL) | 848 ± 5.3 | 16.0 ± 2.0 |
| Tmax (hr) | 1.0 ± 0.0 | 9.3 ± 2.4 |
| AUC ss (μg.hr/mL) | 604 ± 83 | 241 ± 33 |
| T1/2 (hr) | 6.26 ± 0.78 | 6.91 ± 0.53 |
| CL (mL/hr/kg) | 11.8 ± 2.1 | 27.5 ± 2.9 |
| Vss (mL/kg) | 98.0 ± 14.8 | ND |
| MRT (hr) | 6.57 ± 0.42 | 10.4 ± 0.6 |
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