Table 3.
The efficacy of vaccination in smoker and non-smoker for people not previously vaccinated (rate as %)
| Number of people (rate) |
Influenza, vaccine compared to placebo |
|||||
|---|---|---|---|---|---|---|
| Influenza according to | Smoker or non-smoker | vaccine (n=743)a | placebo (n=730)b | rate difference (95% CI)c,d | odds ratio (95% CI)c,e | logistic regression odds ratio (95% CI)c,f |
| Serology | smoker | 4/151 (3%) | 21/166 (13%) | −10% (−16%–−4%) | 0.19 (0.06–0.56) | 0.17 (0.06–0.52)g |
| non-smoker | 34/578 (6%) | 44/552 (8%) | −2% (−5%–1%) | 0.72 (0.45–1.15) | 0.71 (0.45–1.14)g | |
| Sentinel stations | smoker | 8/153 (5%) | 16/168 (9%) | −4% (−10%–2%) | 0.52 (0.22–1.26) | 0.54 (0.22–1.33) |
| non-smoker | 37/590 (6%) | 57/562 (10%) | −4% (−7%–−1%) | 0.59 (0.39–0.91) | 0.58 (0.38–0.90) | |
a
Includes 14 missing values for serological influenza.
bIncludes 12 missing values for serological influenza.
cCI indicates confidence interval.
dAccording to Ref.[14].
eNot corrected for covariables.
fCorrected for age, sex, risk group and protective titre before vaccination.
gDifference in efficacy between smoker and non-smoker was significant (likelihood ratio=11.81; p<0.005; corrected for age, sex and risk group).