Figure 4.

Cancer‐associated fibroblasts (CAFs)‐derived exosomes promoted the aggressive behavior of esophageal squamous cell carcinoma (ESCC) cell lines. A, CAFs‐derived exosomes could promote migration ability of ESCC cell lines with a dose‐dependent effect. B, CAFs‐derived exosomes did not change the morphological character of TE‐1 and EC109. C, Effects of CAFs‐derived exosomes on the proliferation of TE‐1 and EC109 cells was measured by MTS assay. D, Effects of CAFs‐derived exosomes on migration ability of ESCC cell lines. Results shown are representative of three independent experiments. Statistical significance *P < .05, **P < .01 and ***P < .001