Table 2.

p16 and E4 expression in different grades of CIN (n = 318) on worst histological lesion on colposcopy‐directed biopsy

p16	Diagnosis
	No CIN (N = 90)	LSIL/CIN1 (N = 67)	HSIL/CIN2 (N = 95)	HSIL/CIN3 (N = 62)	CC (N = 4)
	E4 positive	E4 positive	E4 positive	E4 positive	E4 positive
0 ‐ negative (N = 103)	0/85 (0%)	7/15 (47%)	0/3 (0%)	0/0 (0%)	0/0 (0%)
1 ‐ lower 1/3 (N = 27)	0/2 (0%)	7/20 (35%)	1/5 (20%)	0/0 (0%)	0/0 (0%)
2 ‐ lower 2/3 (N = 59)	0/3 (0%)	7/15 (47%)	13/27 (48%)	2/14 (14%)	0/0 (0%)
3 ‐>lower 2/3 (N = 129)	0/0 (0%)	6/17 (35%)	7/60 (12%)	0/48 (0%)	0/4 (0%)