Table 2.
Overall survival estimates (HR: hazard ratio and 95% CI: 95% confidence interval) for follicular lymphoma among non-Hispanic and Hispanic White women in the Los Angeles County non-Hodgkin Lymphoma case control study
| Overall (n=230) | non-Hispanic White (n=157) | Hispanic White (n=43) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Univariate | n | HR | 95% CI | n | HR | 95% CI | n | HR | 95% CI | |
| Association of Individual Alleles | rs4938573 | 1.38 | (0.81-2.34) | 1.42 | (0.79-2.53) | 0.79 | (0.13-4.78) | |||
| rs4245081* | 0.98 | (0.60-1.59) | 1.03 | (0.59-1.82) | 0.44 | (0.10-1.94) | ||||
| rs17749561 | 0.57 | (0.22-1.48) | 0.59 | (0.22-1.54) | NA | |||||
| rs13254990 | 0.74 | (0.45-1.20) | 0.83 | (0.49-1.40) | 0.27 | (0.40-1.91) | ||||
| rs12195582 | 0.68 | (0.43-1.07) | 0.62 | (0.37-1.04) | 1.16 | (0.34-4.04) | ||||
| Polygenic risk score (HR, 95% CI) | Tertile 1 | 25 | ref | 14 | ref | 6 | ref | |||
| Tertile 2 | 42 | 0.59 | (0.26-1.36) | 25 | 0.56 | (0.21-1.49) | 12 | 1.4 | (0.13-15.8) | |
| Tertile 3 | 64 | 0.37 | (0.16-0.86) | 50 | 0.29 | (0.11-0.74) | 10 | 1.58 | (0.14-17.5) | |
| p-trend | 0.07 | p-trend | 0.04 | p-trend | 0.93 | |||||
| International Prognostic Index (approximated) | Low | 28 | ref | 17 | ref | 8 | ref | |||
| Med | 132 | 1.32 | (0.46-3.78) | 92 | 0.95 | (0.27-3.27) | 24 | 1.84 | (0.22-15.36) | |
| High | 26 | 4.00 | (1.32-12.16) | 22 | 3.55 | (1.00-12.58) | 2 | 2.81 | (0.17-45.72) | |
| Treatment | ||||||||||
| Surgery | No | 167 | ref | 112 | ref | 35 | ref | |||
| Yes | 63 | 2.06 | (1.20-3.55) | 45 | 2.14 | (1.13-4.06) | 8 | 4.16 | (1.04-16.70) | |
| Chemotherapy | No | 106 | ref | 71 | ref | 21 | ref | |||
| Yes | 124 | 1.01 | (0.59-1.73) | 86 | 1 | (0.53-1.90) | 22 | 0.54 | (0.13-2.25) | |
| Radiotherapy | No | 198 | ref | 135 | ref | 35 | ref | |||
| Yes | 32 | 1.28 | (0.63-2.62) | 22 | 1.21 | (0.51-2.89) | 8 | 2.54 | (0.60-10.60) | |
| Multivariate** | ||||||||||
| Polygenic risk score (HR, 95% CI) | Tertile 1 | 20 | ref | 13 | ref | 4 | ref | |||
| Tertile 2 | 35 | 0.65 | (0.24-1.74) | 22 | 0.76 | (0.23-2.57) | 9 | NA | ||
| Tertile 3 | 54 | 0.32 | (0.13-0.82) | 42 | 0.31 | (0.10-0.96) | 9 | NA | ||
| p-trend | 0.06 | p-trend | 0.11 | p-trend | NA | |||||
| *tagSNP for previous reported rs4937362, Skibola et al 2014 | ||||||||||
**
adjusted for IPI and treatment
Approximated IPI consists of : age (>60), stage (III-IV), extranodal status, and Eastern Cooperative Oncology Group (ECOG) performance score (3-4)