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. Author manuscript; available in PMC: 2020 Sep 16.
Published in final edited form as: Nat Neurosci. 2020 Mar 16;23(4):533–543. doi: 10.1038/s41593-020-0592-z

Figure 3. Genes linked to learning are enriched in the modules of co-expression in reporter+ neurons.

Figure 3.

(a, b) WGCNA analysis of the single cell RNA-sequencing dataset. Clustering dendrogram of genes with assigned module colors (a), from which 9 gene modules of highly correlated genes are identified including 5 modules unique to reporter+ neurons in PAE mice (Blue, Brown, Yellow, Green and Magenta modules) (b). (c-e) GO networks enriched in Brown (c), Yellow (d) and Magenta (e) modules. The broken-line ellipse in the Brown module indicates the fatty acid metabolic process that includes top-ranked genes involved in intellectual disability and autism (genes at higher ranking are indicated as larger nodes). Yellow (d) and Magenta (e) modules include GOs related to learning and ion transport, respectively (broken-line ellipses).