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. Author manuscript; available in PMC: 2020 Sep 9.
Published in final edited form as: Nat Neurosci. 2020 Mar 9;23(4):583–593. doi: 10.1038/s41593-020-0603-0

Extended Data Fig. 4. Cellular expression profiles of brain disorder risk genes.

Extended Data Fig. 4

a. Cellular expression profiles of brain disorder risk genes derived from H-MAGMA and cMAGMA. Psychiatric disorder-associated genes are highly expressed in neurons, while neurogenerative disorder-associated genes show glial signatures. Astro, astrocytes; Micro, microglia; Endo, endothelial cells; Oligo, oligodendrocytes; OPC, oligodendrocytes progenitor cells. b. Psychiatric disorder-associated genes are highly expressed in radial glia and excitatory neurons in the developing cortex. RG, radial glia, vRG; ventricular RG; oRG, outer RG; tRG, truncated RG; IPC, intermediate progenitor cells; Ex, excitatory neurons; In, inhibitory neurons; nEx/nIn, newly born excitatory/inhibitor neurons; PFC, prefrontal cortex; V1, visual cortex; CGE, caudal ganglionic eminence; MGE, medial ganglionic eminence.

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