Figure 2.

CircPRMT5 promoted cell proliferation of CRC in vitro and in vivo. (A). RT‐qPCR for circPRMT5 in SW620 cells was transfected with the shRNAs. Data are mean ± SD. **P < .01; (B). RT‐qPCR for circPRMT5 in HCT‐116 cells transfected with control vector or circPRMT5 overexpression plasmid. Data are mean ± SD. ***P < .001; (C). CCK‐8 assay of CRC cells overexpression of circPRMT5 or down‐regulation of circPRMT5. Data are mean ± SD. *P < .05; (D and E). colony formation assay of CRC cells overexpression of circPRMT5 or down‐regulation of circPRMT5. Data are mean ± SD. **P < .01, ***P < .001; (F). representative images of tumours injected with SW620‐control cells or SW620‐shcircPRMT5 cells; (G). tumour weight in the xenograft model. Data are mean ± SD. n = 5/group. ***P < .001; (H). Growth curve of tumour volumes in the xenograft model. Data are mean ± SD. n = 5/group. *P < .05