Figure 5.

Effect of furanone on the protein expression of LXRs and the effect of LXR antagonists on furanone‐induced protein expression of ABCA1 and lipid accumulation in RAW264.7 macrophages. (A) Effect of the furanone on the protein expression of LXRα and densitometric quantification; (B) effect of the furanone on the protein expression of LXRβ and densitometric quantification; (C) effect of LXR antagonist GSK2033 on furanone‐induced protein expression of ABCA1; (D) effect of LXR antagonist SR9243 on furanone‐induced protein expression of ABCA1; (E) effect of LXR antagonists on furanone‐induced TC lowering; (F) effect of LXR antagonists on furanone‐induced TG lowering. Data are expressed as mean ± SD (n = 4). ^##means P < .01 vs vehicle; *means P < .05 vs model group; **means P < .01 vs model group; ^&means P < .05 vs the corresponding compound alone; ^&&means P < .01 vs the corresponding compound alone; ^{^}means P < .05 vs furanone treatment alone