Table 1.
Summary of heart rate, left ventricular mass, serum blood urea nitrogen (BUN), creatinine and echocardiography measurements
| Sham (N = 11) | CKD (N = 15) | |
|---|---|---|
| HR (min) | 483.5 ± 19.7 | 460.0 ± 14.6 |
| LV mass (g) | 0.105 ± 0.012 | 0.095 ± 0.011 |
| BUN (mg/dL) | 18.9 ± 0.51 | 49.0 ± 12.64a |
| Creatinine (mg/dL) | 0.45 ± 0.01 | 1.24 ± 0.36a |
| LA/AO | 1.35 ± 0.08 | 1.5 ± 0.08 |
| LVIDd (mm) | 0.384 ± 0.013 | 0.4 ± 0.013 |
| LVIDs (mm) | 0.26 ± 0.016 | 0.31 ± 0.02 |
| EDV (mL) | 0.142 ± 0.014 | 0.162 ± 0.015 |
| ESV (mL) | 0.05 ± 0.007 | 0.08 ± 0.014 |
| FS (%) | 32.4 ± 2.5 | 23.1 ± 2.6a |
| SV (mL) | 0.103 ± 0.004 | 0.082 ± 0.003a |
BUN and creatinine levels were increased in CKD mice. The fractional shortening and stroke volume decreased significantly in CKD mice. CKD, chronic kidney disease; HR, heart rate; LV, left ventricular; BUN, blood urea nitrogen; LA/AO, left atrial to aortic root ratio; LVIDd, left ventricular internal diameter at end‐diastole; LVIDs, left ventricular internal diameter at end‐systole; EDV, end‐diastolic volume; ESV, end‐systolic volume; FS, fractional shortening; SV, stroke volume. Values are expressed as the means ± SEM.
a
P < .05 compared to sham mice.