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. 2020 Apr 1;12:2405–2414. doi: 10.2147/CMAR.S237146

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© 2020 Song et al.

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APS upregulated the expression of tumour suppressor genes but reduced the expression of MDR1, and the level of p-AMPK was reduced in adriamycin-resistant gastric cancer SGC-7901/ADR cells.

Notes: Human gastric cancer SGC-7901 cells were incubated with APS (100 µg/mL) and/or adriamycin (0.1 µg/mL) for 24 h. (A) The expression of FBXW7, SEMA3F, P21^WAF1/CIP1, and MDR1 was examined by real-time PCR. (B) and (C) The level of p-AMPK in adriamycin-sensitive gastric cancer SGC-7901 cells, adriamycin-resistant gastric cancer SGC-7901/ADR cells, and human gastric epithelial cells (GES-1). β-Actin was used as a loading control. The relative protein level of p-AMPK was normalized to that of β-actin. Data are expressed as mean ± SD. N = 3–5. **p < 0.01, ***p < 0.001 versus vehicle; ⁺⁺p < 0.01, ⁺⁺⁺p < 0.001 versus GES-1 group; ^#p < 0.05 versus SGC-7901 group.