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. 2020 Apr 1;13:2725–2738. doi: 10.2147/OTT.S236359

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© 2020 Gao et al.

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Inhibition of FSTL3 could inhibit tumor growth and metastasis in vivo. (A) The expression level of FSTL3 in stable cell lines with FSTL3 knocked down was measured by qRT-PCR. (B) FSTL knockdown significantly inhibited tumor growth in xenotransplantation model in nude mice. (C) FSTL3 knockdown significantly reduced the tumor weight of xenotransplantation model in nude mice. (D) HE staining showed that FSTL3 knock down ameliorated lung metastasis of H1299 cell. (E) Incidence and severity of lung metastasis in the mice from two groups. **P<0.01, ***P<0.001.