Table 3.
Univariate and Multivariate Cox Regression Survival Analyses for Overall Survival of Patients with Immature Neuroblastoma
| Variables | Total No. (Death No.) | Univariate Analysis | Multivariate Analysisa | |||
|---|---|---|---|---|---|---|
| HR(95% CI) | P value | HR(95% CI) | P value | |||
| Sex | Female | 25 (13) | 1 (Ref.) | |||
| Male | 31 (12) | 0.63 (0.29–1.37) | 0.241 | |||
| Age | ≤ 18 months | 21 (4) | 1 (Ref.) | |||
| > 18 months | 35 (21) | 4.25 (1.45–12.40) | 0.008 | |||
| INSS stage | 1/2 | 21 (5) | 1 (Ref.) | |||
| 3/4 | 35 (20) | 3.44(1.29–9.19) | 0.014 | |||
| Tumor size | ≤ 5cm | 23 (6) | 1 (Ref.) | |||
| > 5cm | 33 (19) | 2.92 (1.16–7.31) | 0.023 | |||
| Metastasis | Without metastasis | 33 (9) | 1 (Ref.) | |||
| With metastasis | 23 (16) | 3.93 (1.72–8.99) | 0.001 | |||
| NLR | Continuous variable | 56 (25) | 1.16 (0.95–1.42) | 0.146 | ||
| PLR | Continuous variable | 56 (25) | 1.000 (0.996–1.004) | 0.939 | ||
| LMR | Continuous variable | 56 (25) | 0.93 (0.82–1.06) | 0.294 | ||
| SII | Continuous variable | 56 (25) | 1.000 (1.000–1.001) | 0.186 | ||
| CAR | Continuous variable | 56 (25) | 1.55 (1.25–1.92) | < 0.001 | 1.35 (1.07–1.71) | 0.012 |
| CRP | ≤ 10mg/L | 35 (10) | 1 (Ref.) | 1 (Ref.) | ||
| > 10mg/L | 21 (15) | 3.27 (1.46–7.31) | 0.004 | 1.71 (0.67–4.36) | 0.263 | |
| ALB | ≥ 35g/L | 47 (19) | 1 (Ref.) | 1 (Ref.) | ||
| < 35g/L | 9 (6) | 2.12 (0.85–5.32) | 0.109 | 2.81 (1.03–7.68) | 0.044 | |
| GPS | 0 | 32 (8) | 1 (Ref.) | 1 (Ref.) | ||
| 1/2 | 24 (17) | 4.03 (1.73–9.40) | 0.001 | 2.42 (0.89–6.56) | 0.083 | |
| mGPS | 0 | 35 (10) | 1 (Ref.) | 1 (Ref.) | ||
| 1/2 | 21 (15) | 3.27 (1.46–7.31) | 0.004 | 1.71 (0.67–4.36) | 0.263 | |
| Hs-mGPS | 0 | 28 (4) | 1 (Ref.) | 1 (Ref.) | ||
| 1/2 | 28 (21) | 8.94 (3.05–26.26) | < 0.001 | 6.01 (1.84–19.57) | 0.003 | |
| CAR | < 0.0959 | 17 (1) | 1 (Ref.) | 1 (Ref.) | ||
| > 0.0959 | 39 (24) | 15.35 (2.07–113.71) | 0.008 | 12.52 (1.57–100.02) | 0.017 | |
Notes: aMultivariate analyses were adjusted by sex, age, INSS stage, tumor size and metastasis.
Abbreviations: HR, hazard ratio; CI, confidence interval; INSS, International Neuroblastoma Staging System; CAR, C-reactive protein to albumin ratio; NLR, neutrophil to lymphocyte ratio; PLR, platelet to lymphocyte ratio; LMR, lymphocyte to monocyte ratio; SII, system inflammation index; CRP, C-reactive protein; ALB, albumin; GPS, Glasgow Prognostic Score; mGPS, modified GPS; Hs-mGPS, high-sensitivity modified GPS; Ref., reference.