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Definition of Disease Stages in jck Mice and LPK Rats
| Postnatal Age | Stage of Cystic Disease | Definition (Based on Previous Studies) |
|---|---|---|
| Wk 3 LPK rats Wk 4 jck mice |
Early or pre-cystic | Focal cystic disease (cyst area <30%) |
| Wk 6–12 LPK rats Wk 8 jck mice |
Established | Diffuse cystic disease (cyst area >30%) |
| Week 24 LPK rats Week 12 jck mice |
End-stage | Diffuse cystic disease with interstitial fibrosis; Increased mortality due to renal impairment beyond this timepoint |
