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Intrinsic dynamics of hDNMT1 (351–1600). (A) The motion of PCA mode 1 and (B) ANM mode 1 of hDNMT1 (351–1600). (C) Distributions of the mode shapes in GNM mode 1, 2, 3 of hDNMT1 (351–1600), while the global hinge residues are labeled. (D) Structural mapping of global hinges predicted by GNM mode 1 (vertical plane), mode 2 (middle plane), and mode 3 (three triangles) in hDNMT1.
