Fig. 6.

Intra- and inter- domain allosteric interactions in hDNMT1 (351–1600) structure. (A) The local allosteric networks formed by metapaths are represented, with residues shown in small sphere and the links in red, while the long-range paths across RFTS-CD are also represented, with residues shown in big sphere and the links in black. The detailed representation of the local allosteric networks in the catalytic site (B), in the N-lobe and C-lobe of RFTS (C), and in the TRD region (D). The representative long paths across the TRD interface (E) and catalytic interface (F). (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)