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. 2020 Mar 16;30:105435. doi: 10.1016/j.dib.2020.105435

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© 2020 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig 8 — Localized charge changes in anti-IL-13/IL-4 BsIgG species over a pH range from 7 to 9. (a) Models of the bispecific that is either correctly paired or mispaired. Anti-IL-4 is shown in red (heavy chain) and wheat (light chain), anti-IL-13 is dark blue (heavy chain) and light blue (light chain). (b) Views of the correctly paired anti-IL-13/IL-4. For orientation the same views are used in (c–e). (c and d) Surface view of charge changes at pH 9 subtracted from pH 7 for each residue over pH gradient for (c) H1L1/H2L2 or (d) H1L2/H2L1. (e) Identical residue positions of maps (c) and (d) are subtracted for mapping onto the H1L1/H2L2 model. Areas of color change indicate regions with the largest difference charge change over the pH gradient between H1L1/H2L2 and H1L2/H2L1.