Hippocampal time series variance related to percent of time spent in hippocampal FC state. (A) Variance across the 10-min time series was negatively correlated with time spent in state R1 in scan 1 (Spearman: p < 0.0001, ρ = −0.70) (filled). Similar results for scan 2 (open). (B) Variance across the 10-min time series was positively correlated with time spent in state R2 in scan 1 (Spearman: p < 0.0001, ρ = 0.45) (filled). Similar results for scan 2 (open). (C) Example of variance across each window of a healthy control participant (purple, bottom), right TLE patient (middle, cyan) and left TLE patient (top, yellow). The circles indicate the windows in which the participant is in state R2. The variance across the scan (var) and percent of scan spent in state R2 (R2) are indicated for each. No window to window relationship between variance and percent time spent in state R2. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)