Figure 3.

Differential Anaplerotic Shunt in the RPE and Retina

(A–K) Metabolites involved in the TCA cycle were analyzed from neural retina and RPE-choroid. The levels of these metabolites for both neural retina and RPE-choroid are shown (A–H, J, and K) along with a graphical representation of TCA cycle (I), with the significantly elevated metabolites in RPE-choroid boxed in red, those elevated in neural retina marked by underline, and those not measured marked by an asterisk. Each group has a sample size of n = 8 for neural retina and n = 9 for RPE-choroid. The metabolites having significant differences between neural retina and RPE-choroid are shown (A–E) with ∗p < 0.05, ∗∗p < 0.001, ∗∗∗p < 0.0001, and ∗∗∗∗p < 0.00001. Data represented as mean ± SEM. (NR, neural retina; RPE-Ch, RPE-choroid).