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. 2020 Apr 3;6(4):e03728. doi: 10.1016/j.heliyon.2020.e03728

Table 2.

Comparison of biomarker expression in blood and tissue samples.


Control healthy subjects
Breast cancer patients


Blood (n = 50)
Blood (n = 64)
Tissue (n = 64)
Biomarker N(+) N(+) N(+) P1 P2
CEA(O) 11 33 25 0.001∗ NS
erbB2 6 30 51 0.000∗ 0.000∗
MAM 18 30 27 NS NS
ERβ 0 13 16 0.001 NS
CK19 37 63 61 0.000∗ NS
Ki67 22 10 56 0.001∗ 0.000∗
CEA(i) 40 45 39 NS NS
Muc 44 56 62 NS 0.000٭
c-Myc 4 31 26 0.000∗ NS

P1: Chi-Square test was used between the blood of healthy individual and breast cancer patients; P2: Chi-Square test was used between the blood and the tumor of breast cancer patients; ∗: Significant at 0.05(p < 0.05); NS: Non Significant.