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. 2020 Mar 12;19(5):3348–3354. doi: 10.3892/etm.2020.8599

Figure 1.

Figure 1

PVT1 directly regulates the expression of miR-190a-5p in HUVECs. (A) Expression of PVT1 was suppressed by siRNA-PVT1 in HUVECs. ***P<0.001, vs. the mock group; ###P<0.001 vs. siRNA NC group. (B) Expression of miR-190a-5p was promoted by the knockdown of PVT1 in HUVECs. ***P<0.001, vs. the mock group; ###P<0.001 vs. siRNA NC group. (C) PVT1 contains a complementary sequence to miR-190a-5p. (D) Luciferase reporter assay results confirmed the direct interaction between PVT1 and miR-190a-5p. *P<0.05 and **P<0.01, vs. the mock group; #P<0.05 and ##P<0.01 vs. the miR-NC group. HUVEC, human umbilical vein endothelial cells; PVT1, plasmacytoma variant translocation 1; siRNA-PVT1, small interfering RNA targeting PVT1, NC, negative control; WT, wild-type; MT, mutant-type; miR, microRNA.