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. 2020 Mar 6;19(5):3177–3188. doi: 10.3892/etm.2020.8576

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Copyright: © Long et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Fisetin alters cardiomyocyte morphology. (A) Hematoxylin and eosin-stained sections of rat heart tissue following myocardial ischemia/reperfusion (magnification, x400). Myocardial cells in fisetin-pretreated group showed less notable structural changes as well as reduced number of inflammatory cells compared with the model group. The yellow arrow indicates inflammatory cells (infiltrating neutrophils). (B) Inflammatory cell number and the proportion of inflammatory cells, in myocardial tissue, were significantly decreased in fisetin-pretreated groups compared with the model group. ^*P<0.05 and ^**P<0.01 vs. inflammatory cell model; ^ΔΔP<0.01 vs. rate of inflammatory model group.