Figure 8.

Fisetin reduces NF-κB expression in ischemic myocardium. (A) Representative photomicrographs of rat ischemic myocardium stained for NF-κB. (yellow brown; magnification, x400). Yellow arrow in the sham operation group highlights a cell nucleus with no NF-κB localization (stained blue) and the yellow arrow in the model group indicates a cell nucleus showing translocation of NF-κB expression from cytoplasm to nucleus (stained yellow/brown). (B) NF-κB nuclear expression was significantly inhibited in fisetin and quercetin-pretreated groups compared with the model group. (C) Quantification of total NF-κB staining. ^*P<0.05 and ^**P<0.01 vs. model group. NF-κB, nuclear factor-κB.