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Fisetin significantly reduces platelet aggregation rate in human blood samples. (A) Rate of platelet aggregation in fisetin (1x10-9-1x10-5 M), dipyridamole (2x10-6 mol/l), clopidogrel (3x10-5 mol/l), and aspirin (2.8x10-4 mol/l) treated groups was significantly reduced. (B) Antiplatelet effect of fisetin and quercetin was dose dependent with half maximal inhibitory concentration of 4.54x10-7 mol/l and 2.71x10-7 mol/l for fisetin and quercetin, respectively. **P<0.01 vs. control.
