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. 2020 Mar 9;19(5):3247–3258. doi: 10.3892/etm.2020.8586

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Copyright: © Qian et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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IL-35 enhances DEX-induced MKP-1 expression and recruitment of GR to the GRE in monocytes. (A) MKP-1 mRNA expression level was analyzed by reserve transcription-quantitative PCR. SR, n=12; SS, n=12. (B) Schematic of GR binding to GRE upstream of the TSS of the human MKP-1 gene. (C) Amount of GR bound to GRE as measured by chromatin immunoprecipitation analysis. SR, n=6; SS, n=6. Data are presented as the mean ± SD. TSS, transcriptional start site; SR, steroid-resistant; SS, steroid-sensitive; IL, interleukin; DEX, dexamethasone; GR, glucocorticoid receptor; GRE, glucocorticoid response element; MKP-1, mitogen-activated protein kinase phosphatase-1.