Fig. 2.

Striatonigral-enriched genes are decreased in the Nolz-1 KO striatum. (A) Foxp2 is decreased in the Nolz-1 KO striatum compared to the WT striatum of E18.5 brains. (B and C) DARPP-32-positive striosomes (B) and CalDAG-GEF I-positive matrix (C) are decreased in the Nolz-1 KO striatum. (D–F) D1R, (D), SP, (E), Isl1 (F), and Plxn D1 (G), markers of striatonigral neurons are decreased in the Nolz-1 KO striatum. The bracketed regions are shown at high magnification in the Insets. (H) The qRT-PCR assay shows significant reductions of striatonigral-enriched genes in the E18.5 Nolz-1 KO striatum. *P < 0.05; **P < 0.01; n = 3/group. (Scale bars, 200 μm [A–G], and 30 μm [A–G] for the Insets.)