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. 2020 Apr 3;13(4):100767. doi: 10.1016/j.tranon.2020.100767

Figure 4.

Figure 4

Loss of either S6K1 or S6K2 does not attenuate VEGF/bFGF-mediated angiogenesis in vivo. (A) Representative images of Matrigel implants containing a mixture of VEGF and bFGF or heparin only as a control (Ctrl) harvested from S6k1−/− (n = 5), S6k2−/− (n = 5), and wild-type (n = 5) mice at 7 days postinjection. Scale bars: 1 cm. (B) Representative immunofluorescence images of Matrigel plugs stained for CD31 and α-SMA. Scale bars: 50 μm. (C and D) Quantification of MVD (C) and pericyte coverage of CD31-positive vessels (D) in the Matrigel implants. Data are presented as means ± SEM. **P < 0.01.