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. 2020 Apr 3;13(4):100767. doi: 10.1016/j.tranon.2020.100767

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© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Inactivation of either S6k1 or S6k2 does not affect the frequency of CD11b⁺Gr1^hi myeloid-derived suppressor cells or their production of Bv8 in tumors. (A and B) Representative flow cytometry images (A) and quantification (B) of CD11b⁺Gr1^hi myeloid-derived suppressor cells (gated in red boxes) in the blood circulation, bone marrow (BM), and tumors in S6k1^−/−(n = 11), S6k2^−/− (n = 16), and wild-type (n = 24) mice bearing B16F10 xenografts of similar size. (C and D) Representative flow cytometry images (C) and quantification (D) of CD11b⁺Gr1^hi myeloid-derived suppressor cells in the blood circulation, BM, and tumors in S6k1^−/−(n = 22), S6k2^−/− (n = 23), and wild-type (n = 24) mice bearing LLC xenografts of similar size. (E and F) Intratumoral Bv8 concentration assessed by ELISA in B16F10 (E) and LLC (F) xenografts. Data are presented as box plots with medians and minimum to maximum whiskers.