Fig. 5.
T2D BKS.Leprdb/db mice display reductions in RPE function by the dc-ERG that precede reductions in photoreceptor function. Bar graphs show c-wave (A), fast oscillation (B), light peak (C), and off response amplitude (D) of BKS.Lepr+/+,db/+ and BKS.Leprdb/db mice at the ages tested. Results for B6.BKS.Lepr+/+,db/+ mice are shown in black and for Leprdb/db mice in gray. Data points indicate average ± SE of at least 3 mice for each group. Boxes surrounding ages indicate times of hyperglycemia. E: representative dc-ERG waveform traces at each age. BKS.Lepr+/+,db/+ traces are shown in black and BKS.Leprdb/db traces in gray. F: relative amplitude of the a-wave, c-wave, fast oscillation, and off response as a function of age. Data are normalized to responses obtained from control BKS.Lepr+/+,db/+ littermates. Student's t-test was performed between genotypes at each time point. *P < 0.05; **P < 0.001; ***P < 0.0001.