Figure 3. Telomere fusions in senescent cells contain short telomere arrays.

1. Distribution of the telomere repeat array found at the junction between two fused chromosomes of senescent cells transduced with lentiviral vectors expressing either shControl or shRAP1. Variant telomere repeats were included in the estimation of the telomere array length. Data represent median ± interquartile range (green lines) of three biological replicates. Statistical analysis was performed using Mann–Whitney U‐test ***P < 0.0001).
2. Examples of DNA sequences found at the telomere fusion points of shControl and shRAP1 conditions. Telomere repeats are underlined in blue, while variant telomere repeats are underlined in red. The sequence ID corresponds to the identifier in Table EV1.