Table 2.
Quantification of antiviral activity of CBA (plant lectins and pradimicin-A) by the immunoperoxidase assay
| CBA | MHV-EFLM | FIPV Black TN406HP (serotype I) | FIPV-Δ3abcFL (serotype II) | FCoV 79-1683 (serotype II) | PRRSV Lelystad virus |
|---|---|---|---|---|---|
| GNA | 0.04 ± 0.02 | 0.012 ± 0.006 | 0.07 ± 0.04 | 0.2 ± 0.06 | >2 |
| HHA | 0.07 ± 0.02 | 0.004 ± 0.002 | 0.03 ± 0.02 | 0.06 ± 0.02 | >2 |
| UDA | 0.53 ± 0.02 | 0.02 ± 0.01 | 0.14 ± 0.05 | 0.17 ± 0.10 | 4.8 ± 3.2 |
| PRM-A | 10.7 ± 5.8 | 7.8 ± 2.0 | >120 | >120 | >120 |
Antiviral activity of G. nivalis agglutinin (GNA), Hippeastrum hybrid agglutinin (HHA), U. dioica agglutinin (UDA) and pradimicin-A (PRM-A) against murine and feline coronaviruses and the arterivirus PRRSV. Values represent the CBA concentrations resulting in 50% inhibition of virus infection (EC50 ± S.D.) and are expressed in μM.