Table 2.
Refractory patients (n = 192)
| Prior antifungal therapy | No. of patients | Duration of therapy (days) |
Last dose administered (mg) |
||
|---|---|---|---|---|---|
| Mean | Range | Mean | Range | ||
| Amphotericin B (lipid) (mg/kg) | 148 | 23 | 1–237 | 341.5 (6.09) | 25–1425 (1.8–19.2) |
| Fluconazole | 87 | 32 | 1–356 | 211.1 | 22–400 |
| Amphotericin B (deoxycholate) (mg/kg) | 86 | 16 | 1–130 | 54.2 (0.94) | 9–110 (0.1–2.3) |
| Itraconazole | 66 | 47 | 1–1786 | 299.7 | 30–800 |
| Caspofungin | 7 | 24 | 1–71 | 39.3 | 15–50 |
| Voriconazole | 5 | 57 | 12–144 | 326.4 | 72–700 |
| Posaconazole | 5 | 13 | 4–25 | 680 | 200–800 |
| Flucytosine | 3 | 7 | 4–9 | 3633.3 | 2000–6400 |
| Terbinafine | 2 | 35 | 29–41 | 625 | 250–1000 |
Note: Patients may have received more than one antifungal prior to enrollment.