Table 1.

Antagonism of type I IFN responses by PRRSV.

Viral proteins	Function
nsp1	Inhibits IRF3 phosphorylation and nuclear translocation Mediates CBP degradation Inhibits NF-κB-responsive promoter activation Induces degradation of karyopherin-α1 and inhibits nuclear translocation of ISGF3
nsp2	Prevents the polyubiquitination and degradation of IκBα Suppresses activation of IRF-3 Interferes with ISG15 conjugation to cellular proteins
nsp4	Mediates the cleavage of NEMO and suppresses NF-κB activation
nsp11	Inhibits NF-κB and IRF3 promoter activation
N	Inhibits poly(I:C)-mediated IRF3 phosphorylation and nuclear translocation