Table II.
Overall and site-specific rates of infection in intention-to-treat analysis according to study groups
| Variable | Mupirocin | Placebo | P value | Odds ratio | 95% CI |
|---|---|---|---|---|---|
| Total infections | 18 (13.8%) | 11 (8.6%) | 0.266 | 1.61 | 0.69–3.75 |
| Sternal infections | 7 (5.4%) | 6 (4.7%) | 1.00 | 1.14 | 0.37–3.50 |
| Leg infections | 11 (8.5%) | 5 (3.9%) | 0.196 | 2.25 | 0.76–6.66 |
| NNIS wounds: | |||||
| Superficial | 17 (13%) | 9 (7.1%) | – | – | – |
| Deep | 1 (0.8%) | 1 (0.8%) | – | – | – |
| Deep space occupying | 0 (0%) | 1 (0.8%) | – | – | – |
| In-hospital wound infections | 2 (1.6%) | 3 (2.4%)a | 0.672 | 0.65 | 0.10–3.93 |
| Nosocomial S. aureus infections | 0 (0%) | 2 (1.6%)b | 0.243 | – | – |
| Total S. aureus infections | 5 (3.8%) | 4 (3.2%) | 1.00 | 1.23 | 0.32–4.69 |
S. aureus, Staphylococcus aureus; NNIS, Nosocomial Infection Surveillance System; CI, confidence interval.
a
Two of these infections were due to S. aureus (and listed in the row below) and the rest were leg wounds either not cultured or yielding no organism.
b
Both patients had S. aureus bacteraemia.