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. 2020 Jan 21;28(4):1092–1104. doi: 10.1016/j.ymthe.2020.01.021

Figure 4.

Figure 4

Knockdown of UBR-Ubiquitin Ligases of the Arg/N-degron Pathway Potentiates the Action of Apoptosis-Inducing Drugs In Vitro

(A) Proliferation of Hepa 1–6 cells after exposure to siRNA and doxorubicin (left) or doxorubicin alone (right). (B) Analysis of cell death by TUNEL in Hepa 1–6 cells after 72 h of exposure to 1 nM siRNA against Ubrs and an additional 48 h to doxorubicin. Red nuclei represent TUNEL-positive cells. Scale bar, 100 μm. (C) Quantification of the results in (B). Results show mean ± SD. p values were determined by a one-way ANOVA (****p < 0.0001).