Figure 3.
Dose Comparison for Intratumoral p(aCTLA-4) or pNull Electrotransfer
MC38-bearing C57BL/6J mice received three or six intratumoral electroporations (indicated by black and gray arrows, respectively) of 60 μg p(aCTLA-4) or an equimolar amount of pNull. Control mice were left untreated. (A) Tumor growth and number of complete responders (CR). Tumor volumes, represented as mean + SEM, were compared with one-way ANOVA on day 19 after tumor cell injection, when the first mice had to be sacrificed (*p < 0.05, **p < 0.01, ****p < 0.0001). (B) Correlation between tumor volumes and anti-CTLA-4 mAb plasma concentrations on day 19 after tumor cell injection. R2 indicates the square of the Pearson correlation coefficient (n = 10 or 11 mice per group). For mAb plasma concentrations over time and Kaplan-Meier survival curves, see Figure S3.