Figure 6.

Engineered MSCs Protected Mice against DSS-Induced Colitis

Mice were intravenously injected with different types of MSCs (96 h post-infection) on days 4, 6, and 8 (three times in total). (A and B) Survival analysis was performed (A), and body weight was measured daily to monitor colitis severity (B). (C) Colons excised from mice with DSS-induced colitis were photographed. (D and E) The DAI was determined (D), and the colon length was measured (E). (F) Colonic MPO activity was examined. (G and H) Colon sections from mice that had undergone different treatments were examined by H&E staining (G), and histopathological scoring was analyzed (H). Scale bars, 100 μm. Values are expressed as the mean ± SEM (n = 7 mice per group). *p < 0.05; **p < 0.01; ***p < 0.001.