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. 2005 Jun 28;17(4):691–710. doi: 10.1016/S0733-8619(05)70162-6

Table 6.

EMPIRIC THERAPEUTIC TRIALS IN THE CHRONIC MENINGITIS SYNDROME

Cause Therapy
TB

  • Triple therapy (isoniazid + vitamin B6, rifampin, pyrazinamide)

  • Multidrug resistant strains require 4–5 drugs
Unusual bacteria

  • Broad-spectrum antibiotics

  •  • penicillin, ceftriaxone, (Actinomycetes, spirochetes)

  •  • doxycycline, rifampin (Brucella)

  •  • streptomycin, gentamycin (F. tularensis)
Fungal

  • Antifungal agents

  •  • amphotericin B

  •  • flucytosine

  •  • fluconazole

  •  • miconazole, ketoconazole, itraconazole
Noninfectious Glucocorticoids ± immunosuppressants