Table 2.
mariPOC performance characteristics (in relation to PCR reference methodology).
| Virus | No. of specimens with results |
% sensitivity (95% CI) | % specificity (95% CI) | % positive predictive value (95% CI) | % negative predictive value (95% CI) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Total PCR positive | mariPOC positive PCR positive | mariPOC negative PCR positive | mariPOC positive PCR negative | mariPOC negative PCR negative | |||||
| RSV | 102 | 80 | 22 | 1 | 130 | 78.4 (69.7–85.6) | 99.2 (96.3–100.0) | 98.8 (94.1–99.9) | 85.5 (79.3–90.5) |
| hMPV | 15 | 9 | 6 | 0 | 218 | 60.0 (34.5–81.9) | 100.0 (98.6–100.0) | 100.0 (71.7–100.0) | 97.3 (94.5–98.9) |
| IFV-B | 11 | 7 | 4 | 0 | 222 | 63.6 (33.6–87.2) | 100.0 (98.7–100.0) | 100.0 (65.2–100.0) | 98.2 (95.8–99.4) |
| IFV-A | 6 | 4 | 2 | 1 | 226 | 66.7 (26.2–94.0) | 99.6 (97.9–100.0) | 80.0 (33.4–99.0) | 99.1 (97.1–99.9) |
| ADV | 8 | 1 | 7 | 0 | 225 | 12.5 (0.6–48.0) | 100.0 (98.7–100.0) | 100.0 (5.0–100.0) | 97.0 (94.1–98.7) |
| Parainfluenza-1/-2/-3 virus | 3 | 1 | 2 | 2 | 228 | - | - | - | - |
| Total for mariPOC viral panel | 139 | 102 | 37 | 2 | 92 | 73.4 (65.6–80.2) | 97.9 (93.2–99.6) | 98.1 (93.8–99.7) | 71.3 (63.1–78.6) |
| Total for PCR panel | 188 | 103 | 85 | 1 | 44 | 54.8 (47.6–61.8) | 97.8 (89.5–99.9) | 99.0 (95.4–100.0) | 34.1 (26.3–42.6) |