Figure 6. . Methylation landscape of a CpG-dense region in the 5′-untranslated region of MARCH4 in oral and pharyngeal squamous cell carcinoma cell lines and primary non-neoplastic oral epithelial cells.

(A) The cytogenic band location is displayed at the top of the figure, (B) followed by the position of the CpG-dense region within the gene – highlighted in green – and (C) overlapping and proximal regulatory elements annotated in ORegAnno, with the area spanned by the CpG-dense region highlighted in green. (D) In the methylation plot, CpGs are represented by each point on each line and are accompanied by vertical bars representing standard error. CpGs corresponding to those represented on the Infinium HumanMethylation450 bead array are shown below the methylation plot.