Table 3. . Correlation between gene expression and methylation of select targeted regions.
| Differentially-methylated CpG-dense region | Associated gene | Genomic context | Difference in % methylation of cancer lines vs control cells | Correlation between expression and methylation | |
|---|---|---|---|---|---|
| Spearman (ρ) | pcorrelation | ||||
| chr12:118725604–118725889 | CIT | Intron 9 | 57% | -0.9 | 0.04 |
| chr12:28015205–28015607 | PTHLH | Intron 1 | 44% | 0.9 | 0.04 |
| chr11:2511970–2512178 | KCNQ1 | Intron 2 | -50% | -1.0 | <0.0001 |
| chr16:85998896–85999146 | ZCCHC14 | 3′UTR | -9% | 0.2 | 0.75 |
| chr2:216945117–216945376 | MARCH4 | 5′UTR | 2% | 0.9 | 0.04 |
| chr5:10702368–10702990 | ANKRD33B | Exon 4 | 78% | 0.3 | 0.64 |