Figure 1. . N6-methyladenosine affects many aspects of RNA metabolism.

(A) mRNA stability – YTHDF2 specifically reads m⁶A marked transcripts localizing the mRNA to P-bodies for degradation. (B) Translation – YTHDF1 and 3 specifically recognize m⁶A marked transcripts, resulting in enhanced translation through a closed-loop model. (C) Splicing – YTHDC1 is a m⁶A reader which directs the splicing factor SRSF3 to its target, resulting in exon inclusion. (D) miRNA processing – HNRNPA2/B1, in complex with DGCR8, recognizes primary miRNAs modified by m⁶A delivering DGCR8 to its target for enhanced miRNA processing.

m⁶A: N6-methyladenosine.