Table 1. . Role of N6-methyladenosine in neurodevelopment.

Developmental pathway	Related enzymes and proteins	Role of m6A	Key publications
Cerebellar development	METTL3: KO negatively affects Purkinje cell numbers, laminal structure, dendrite formation and the organization of glial cell fibers	m6A both positively and negatively modulates gene expression of genes important in proper cerebellar development	Ma et al. (2018) [36] Chang et al. (2017) [37]
Neurogenesis	METTL14: KO results in a reduction in cortical length and thickness FMRP: KO results extended neuronal progenitor cell cycle FTO: KO leads to decreased brain size and body weight YTHDF2: KO has a strong negative impact on NSPC self-renewal and neuron generation in embryonic neocortex	m6A marks transcripts for degradation to ensure proper cortical neurogenesis m6A is involved in transcriptional pre-patterning for cortical neurogenesis m6A could regulate the BDNF pathway, and this may be linked to postnatal neurogenesis	Yoon et al. (2017) [35] Wang et al. (2018) [43] Edens et al. (2019) [44] Zhang et al. (2018) [45] Li, Weng et al. (2017) [46] Li, Zhao et al. (2018) [47]
Synaptogenesis	YTHDF1 and 3: KO results in altered spine morphology, dampened excitatory synaptic transmission, and altered cell-surface protein content	m6A marked mRNAs known to function in synaptic plasticity	Merkurjev et al. (2018) [48] Koranda et al. (2018) [49]

m⁶A: N6-methyladenosine; NSPC: Neural stem/progenitor cell.