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. 2020 Mar 30;13(3):dmm042515. doi: 10.1242/dmm.042515

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Arx^(GCG)10+7 expansion mutants do not exhibit microglial invasion or activation in the forebrain at P7. (A-F) Representative images of WT (A-C) and Arx^(GCG)10+7 (D-F) neocortex at P7 showing IBA-1 (A,D) and CD68 (B,E) immunoreactivity, and merged images plus DAPI (C,F). Open arrowheads indicate IBA-1⁺ cells and filled arrowhead indicates a IBA-1⁺ cell with CD68⁺ nucleus. (G,H) Mean IBA-1⁺ cells that are CD68 immunoreactive per mm² in the motor cortex (Motor) (P=0.5562, Mann–Whitney test) (G) and hippocampus (Hipp) (P=0.3260, Mann–Whitney test) (H). (I,J) Mean IBA-1⁺ cells per mm² in the motor cortex (Motor) (P=0.2093, unpaired Student's t-test) (I) and hippocampus (Hipp) (P=0.2748, unpaired Student's t-test) (J). N=8 WT, N=7 Arx^(GCG)10+7. Scale bars: 100 µm. Means±s.e.m. are displayed; exact N values are displayed on graphs.