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. 2020 Mar 30;13(3):dmm042515. doi: 10.1242/dmm.042515

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© 2020. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — E2 treatment modifies neonatal cellular pathology in Arx^(GCG)10+7. (A-C) Effect of P3-P7 40 µg/kg/day E2 treatment compared to vehicle (Veh) treatment (sesame oil) on CC3⁺ cell counts and Arx⁺ cell density in Arx^(GCG)10+7 at P7. (A) Mean CC3⁺ counts in neocortex with E2 treatment (P=0.6548; unpaired Student's t-test). (B,C) Mean Arx⁺ cell density with E2 treatment in RSA (P=0.2804, unpaired Student's t-test) (B) and motor cortex (P=0.0004, unpaired Student's t-test) (C). (D) Mean neocortical Arx⁺ CC3⁺ co-labeled cell counts with E2 treatment (P=0.8177, unpaired Student's t-test). ***P<0.001. Means±s.e.m. are displayed. All N values are displayed on graphs.