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. 2020 Jan 15;28(4):1154–1166. doi: 10.1016/j.ymthe.2020.01.013

Figure 3.

Figure 3

miR-206 Ameliorated Growth Curve and Motor Behavioral Performances of SMA Mice

(A) Growth curves of WT+NT-miR (white squares, continuous line); WT+miR-206 (light gray squares, dashed line); SMA+NT-miR (black triangles, continuous line); SMA+miR-206 (dark gray triangles, dashed line) mice. (B) A representative picture of P9 littermates: SMA+NT-miR; SMA+miR-206; WT+NT-miR. (C, E, and G–J) Righting (C), negative geotaxis (E), tailing suspension (G and H), and hind limb suspension (score; I and J) tests of WT+NT-miR; WT+miR-206; SMA+NT-miR; SMA+miR-206 pups. (D and F) Contingency table for righting (D) and negative geotaxis (F) tests for SMA+NT-miR (black column) and SMA+miR-206 (gray) mice. (H and J) Scattered graph plots of tailing (H) and hind limb (J) scores of each SMA+NT-miR (black triangle) and SMA+miR-206 (gray) animal at P4, P9, and P11. *p < 0.05; **p < 0.005; ***p < 0.001; ****p < 0.0001 SMA+miR-206 versus SMA+NT-miR by 2-ways ANOVA analysis (A, C, E, G, and I), by one-way ANOVA analysis (H and J) followed by Bonferroni test and by Fisher exact test for (D) and (F).