Table 4.

Biological activity of derivatives containing a nitro, amino, methoxy or chloro group in the cinnamylidene substituent.

Microorganism	Compound
	12a	12b	13a	13b	14a	14b	15a	15b	16	17
	MIC (mg/L)
S. aureus ATCC 25923	250	15.6	15.6	7.8	1000	125	62.5	31.25	500	125
S. aureus ATCC 6538	500	250	125	62.5	500	125	15.6	31.25	250	125
S. aureus ATCC 43300	500	15.6	62.5	7.8	500	62.5	62.5	31.25	250	125
S. epidermidis ATCC 12228	1000	3.9	31.25	1.98	500	62.5	31.25	31.25	1000	125
M. luteus ATCC 10240	250	250	500	31.25	250	62.5	125	31.25	500	125
B. subtilis ATCC 6633	500	1000	62.5	3.9	500	62.5	15.6	31.25	250	62.5
B. cereus ATCC 10876	500	>1000	125	62.5	500	125	15.6	31.25	125	125
S. pyogenes ATCC 19615	500	31.25	125	62.5	>1000	125	62.5	125	500	>1000
S. pneumoniae ATCC 49619	125	125	62.5	62.5	500	125	31.25	62.5	250	>1000
S. mutans ATCC 25175	1000	>1000	1000	500	>1000	125	250	125	1000	>1000